Best hits of 11110110111: model-free selection and parameter-free sensitivity calculation of spaced seeds

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All hits all the time: parameter-free calculation of spaced seed sensitivity

MOTIVATION Standard search techniques for DNA repeats start by identifying small matching words, or seeds, that may inhabit larger repeats. Recent innovations in seed structure include spaced seeds and indel seeds which are more sensitive than contiguous seeds. Evaluating seed sensitivity requires (i) specifying a homology model for alignments and (ii) assigning probabilities to those alignment...

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All Hits All The Time: Parameter Free Calculation of Seed Sensitivity

Standard search techniques for DNA repeats start by identifying seeds, that is, small matching words, that may inhabit larger repeats. Recent innovations in seed structure have led to the development of spaced seeds [8] and indel seeds [9] which are more sensitive than contiguous seeds (also known as k-mers, k-tuples, l-words, etc.). Evaluating seed sensitivity requires 1) specifying a homology...

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ژورنال

عنوان ژورنال: Algorithms for Molecular Biology

سال: 2017

ISSN: 1748-7188

DOI: 10.1186/s13015-017-0092-1